BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Abeta-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimers disease research[1][2][3].
Molecular Weight:
233.70
Purity:
96.96
CAS Number:
[205437-64-5]
Formula:
C12H12ClN3
Target:
Apoptosis,Imidazoline Receptor,TNF Receptor
Application Notes:
MCE Product type: Reference compound1
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