Filibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp). Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5B. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM for both isoforms, respectively[1]. Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation[2].
Molecular Weight:
503.64
Purity:
99
CAS Number:
[877130-28-4]
Formula:
C29H37N5O3
Target:
DNA/RNA Synthesis,HCV
Application Notes:
MCE Product type: Reference compound
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