JNJ-39758979, a chemical probe, is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity[1][2].
Molecular Weight:
221.31
Purity:
99.71
CAS Number:
[1046447-90-8]
Formula:
C11H19N5
Target:
Histamine Receptor
Application Notes:
MCE Product type: Reference compound
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