Linsidomine hydrochloride (SIN-1 chloride) is a spontaneous ROS/RNS generator and peroxynitrite donor. Linsidomine hydrochloride is a vasodilator and platelet aggregation inhibitor. Linsidomine hydrochloride induces oxidative stress-induced chondrocyte apoptosis and necrosis. Linsidomine hydrochloride inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of Linsidomine hydrochloride shows protective effects on Zn2+ treated nerve cells[1][2][3][4].
Molecular Weight:
206.63
Purity:
99.97
CAS Number:
[16142-27-1]
Formula:
C6H11ClN4O2
Target:
Annexin A,Apoptosis,Autophagy,NF-kappaB,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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