ICI 185282 is a potent, selective, orally active thromboxane A2 (TXA2) receptor antagonist. ICI 185282 causes dose-dependent inhibition of U-46619 (HY-108566)-induced platelet aggregation ex-vivo in guinea-pig. ICI 185,282 inhibits bronchospasm induced by U-46619, PGD2 (HY-101988), PGF2alpha (HY-12956), arachidonic acid (HY-109590), LTD4 and PAF (HY-108635) in vivo. ICI 185282 can be used for bronchial asthma research[1].
Molecular Weight:
374.35
CAS Number:
[106393-80-0]
Formula:
C18H21F3O5
Target:
Prostaglandin Receptor
Application Notes:
MCE Product type: Reference compound
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