SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 µM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 µM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain[1][2][3][4].
Molecular Weight:
161.16
Purity:
98
CAS Number:
[31137-74-3]
Formula:
C6H11NO4
Target:
Bcl-2 Family,Caspase,EAAT,iGluR
Application Notes:
MCE Product type: Reference compound
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