L 741742 is a dopamine receptor D4 (DRD4) antagonist that selectively inhibits glioblastomas (GBM) growth in vitro and in vivo, synergyed with Temozolomide (TMZ) (HY-17364). L 741742 disrupts in effectors PDGFRbeta/ERK1/2 and mTOR signaling. Additionally, L 741742 disrupts endolysosmal function compromising the autophagy-lysosomal degradation pathway, followed by G0/G1 cell cycle arrest and Apoptosis. L 741742 is promising for research of GBM and neurogenesis[1].
Molecular Weight:
380.91
CAS Number:
[156337-32-5]
Formula:
C23H25ClN2O
Target:
Apoptosis,Dopamine Receptor
Application Notes:
MCE Product type: Reference compound
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