CGP 12177 (()-CGP 12177) hydrochloride is a beta-Adrenergic receptor (beta-AR) ligand. CGP 12177 hydrochloride is a beta3-AR (Ki = 88 nM) agonist with beta1/beta2-AR (Ki = 0.9 nM for beta1, Ki = 4 nM for beta2) antagonist action. CGP 12177 hydrochloride exhibits partial agonist properties for alpha1-AR in rat pulmonary artery. CGP 12177 hydrochloride regulates the expression of ucp and leptin genes in NMRI mice adipose tissues. CGP 12177 hydrochloride can be used for cardiovascular and metabolic disease research[1][2][3][4].
Molecular Weight:
315.80
Purity:
99.69
CAS Number:
[64208-32-8]
Formula:
C14H22ClN3O3
Target:
Adrenergic Receptor
Application Notes:
MCE Product type: Reference compound1
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