ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 µM and 14.3 µM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells[1][2].
Molecular Weight:
269.63
Purity:
99.20
CAS Number:
[582323-16-8]
Formula:
C11H6ClF2N3O
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound
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