Indantadol (the free base of CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol blocks the binding of [H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 µM. Indantadol completely inhibits dopamine release caused by NMDA. Indantadol protects neurons, with an ED50 of 35 µM. Indantadol has anticonvulsant and anti-high pain hypersensitivity activities[1][2][3].
Molecular Weight:
190.24
CAS Number:
[202844-10-8]
Formula:
C11H14N2O
Target:
iGluR,Monoamine Oxidase
Application Notes:
MCE Product type: Reference compound
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