SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg)[1].
Molecular Weight:
265.31
CAS Number:
[223788-33-8]
Formula:
C15H15N5
Target:
Apoptosis,Src
Application Notes:
MCE Product type: Reference compound1
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