TMI-1 (Standard), CAS [[287403-39-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-101448R
Supplier Catalog Number:
HY-101448R
Alternative Catalog Number:
MCE-HY-101448R-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
TMI-1 (Standard) is the analytical standard of TMI-1 (HY-101448). This product is intended for research and analytical applications. TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-alpha , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-alpha,IL-1beta,IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions[1][2][3][4].
