PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively[1].
Molecular Weight:
372.78
Purity:
98.76
CAS Number:
[1035638-91-5]
Formula:
C18H14ClFN4O2
Target:
EGFR
Application Notes:
MCE Product type: Reference compound
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