Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.
Molecular Weight:
453.56
Purity:
99.94
CAS Number:
[1951483-29-6]
Formula:
C22H27N7O2S
Target:
ERK
Application Notes:
MCE Product type: Reference compound
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