ARQ 069, an analog of ARQ 523, inhibits FGFR in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases (IC50s of 0.84 µM and 1.23 µM, respectively). ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC50s of 2.8 and 1.9 µM, respectively) through a mechanism in a non-ATP competitive dependent manner[1].
Molecular Weight:
273.33
CAS Number:
[1314021-57-2]
Formula:
C18H15N3
Target:
FGFR
Application Notes:
MCE Product type: Reference compound
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