NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor[1][2].
Molecular Weight:
445.38
Purity:
99.98
CAS Number:
[324523-20-8]
Formula:
C24H26Cl2N2O2
Target:
CaSR
Application Notes:
MCE Product type: Reference compound
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