Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of [1]. Dasatinib hydrochloride also induces apoptosis and autophagy.
Molecular Weight:
524.47
Purity:
99.67
CAS Number:
[854001-07-3]
Formula:
C22H27Cl2N7O2S
Target:
Apoptosis,Autophagy,Bcr-Abl,Src
Application Notes:
MCE Product type: Reference compound1
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