Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3alpha/beta inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/beta-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy[1][2][3].
Molecular Weight:
465.34
Purity:
99.76
CAS Number:
[252917-06-9]
Formula:
C22H18Cl2N8
Target:
Autophagy,GSK-3,Organoid,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound1
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