A-81282 (Abbott 81282) is an antagonist of angiotensin IIs AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats[1].
Molecular Weight:
429.47
CAS Number:
[141872-46-0]
Formula:
C23H23N7O2
Target:
Angiotensin Receptor
Application Notes:
MCE Product type: Reference compound1
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