Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3alpha/beta inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/beta-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy[1][2][3].
Molecular Weight:
574.72
Purity:
99.11
CAS Number:
[1782235-14-6]
Formula:
C22H21Cl5N8
Target:
Autophagy,GSK-3,Organoid,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound1
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