GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury[1][2][3].
Molecular Weight:
419.95
Purity:
98.85
CAS Number:
[2703752-81-0]
Formula:
C19H18ClN3O2S2
Target:
RIP kinase
Application Notes:
MCE Product type: Reference compound
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