hVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 µM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression[1].
Molecular Weight:
581.75
Purity:
99.26
CAS Number:
[1637443-98-1]
Formula:
C34H43N7O2
Target:
VEGFR
Application Notes:
MCE Product type: Reference compound
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