BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy[1][2][3].
Molecular Weight:
896.05
Purity:
99.10
CAS Number:
[246146-55-4]
Formula:
C49H57N11O6
Target:
Neuropeptide Y Receptor
Application Notes:
MCE Product type: Reference compound
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