ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].
Molecular Weight:
413.83
Purity:
99.80
CAS Number:
[1523437-16-2]
Formula:
C16H16ClN3O6S
Target:
Apoptosis,Eukaryotic Initiation Factor (eIF),PERK
Application Notes:
MCE Product type: Reference compound
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