EM20-25 is an inhibitor for Bcl-2, which interferes with the interaction between BCL-2 and BAX, activates caspase-9 and thus induces the apoptosis. EM20-25 affects the mitochondrial function, causes the open of permeability transition pore (PTP). EM20-25 enhances the sensitivity of cells to Staurosporine (HY-15141), and enhances the killing effect of BCL-2-expressing leukemia cells to Chlorambucil (HY-13593) and Fludarabine (HY-B0069)[1].
Molecular Weight:
376.71
CAS Number:
[141266-44-6]
Formula:
C15H9ClN4O6
Target:
Apoptosis,Bcl-2 Family,Caspase
Application Notes:
MCE Product type: Reference compound
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