Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRbeta, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].
Molecular Weight:
464.83
Purity:
99.92
CAS Number:
[284461-73-0]
Formula:
C21H16ClF3N4O3
Target:
Apoptosis,Autophagy,Ferroptosis,FLT3,Raf,VEGFR
Application Notes:
Reference compound
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