Sorafenib-13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRbeta, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].
Molecular Weight:
468.84
Purity:
98.35
CAS Number:
[1210608-86-8]
Formula:
C20 13CH13D3ClF3N4O3
Target:
Apoptosis,Autophagy,Ferroptosis,FLT3,Raf,VEGFR
Application Notes:
Isotope-Labeled Compounds
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