FM-381, a chemical probe, is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively[1].
Molecular Weight:
428.49
Purity:
98.08
CAS Number:
[2226521-65-7]
Formula:
C24H24N6O2
Target:
JAK
Application Notes:
MCE Product type: Reference compound
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