Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRalpha, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair[1][2][3]. Antineoplastic activity[4].
Molecular Weight:
447.51
Purity:
99.40
CAS Number:
[850879-09-3]
Formula:
C23H21N5O3S
Target:
Apoptosis,c-Kit,c-Met/HGFR,FLT3,PDGFR,RAD51,RET
Application Notes:
MCE Product type: Reference compound
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