GKL003 is a bacterial transcription inhibitor that targets the RNAP-sigma interaction interface, with a Ki of 5.79 nM. GKL003 specifically binds to the RNAP beta clamp helix region at the sigmaA factor binding site, blocks the formation of RNAP holoenzyme, and inhibits the formation of bacterial transcription initiation complexes. GKL003 inhibits the growth of both Gram-positive and Gram-negative bacterial cells, and also exhibits activity against drug-resistant strains[1].
Molecular Weight:
659.52
CAS Number:
[1445801-61-5]
Formula:
C34H28Cl2N4O6
Target:
Bacterial,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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