Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRalpha/beta (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity[1][2][4].
Molecular Weight:
498.64
Purity:
99.95
CAS Number:
[790299-79-5]
Formula:
C28H30N6OS
Target:
Apoptosis,c-Kit,FAK,FGFR,PDGFR,Src
Application Notes:
Reference compound
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