Simeprevir (TMC435, TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][4].
Molecular Weight:
749.94
Purity:
99.90
CAS Number:
[923604-59-5]
Formula:
C38H47N5O7S2
Target:
DNA/RNA Synthesis,HCV,HCV Protease,SARS-CoV
Application Notes:
Reference compound
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