Ciluprevir (BILN 2061, BILN 2061ZW) is an orally active macrocyclic peptide inhibitor of hepatitis C virus (HCV)NS3 protease, with an IC50 of 3 nM. Ciluprevir has K values of 0.66 nM and 0.30 nM against genotypes 1b and 1a, respectively. Ciluprevir inhibits HCV RNA replication with an EC50 of 1.2 nM, and its EC50 values against genotypes 1b and 1a are 3 nM and 4 nM, respectively. Ciluprevir shows no significant inhibition against human leukocyte elastase and hepatic cathepsin B. Ciluprevir can be used for genotype 1 HCV infection[1][2][3].
Molecular Weight:
774.93
Purity:
98.08
CAS Number:
[300832-84-2]
Formula:
C40H50N6O8S
Target:
DNA/RNA Synthesis,HCV,HCV Protease
Application Notes:
MCE Product type: Reference compound
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