BMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy[1][2].
Molecular Weight:
530.55
Purity:
98.56
CAS Number:
[714971-09-2]
Formula:
C27H27FN8O3
Target:
EGFR
Application Notes:
MCE Product type: Reference compound
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