Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC50 of 0.33 nM. Mirdametinib exhibits a Kiapp of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the expression of p-ERK1/2 and induces apoptosis. Mirdametinib has anti-cancer activity for a broad spectrum of human tumor xenografts[1][2][3].
Molecular Weight:
482.19
Purity:
99.95
CAS Number:
[391210-10-9]
Formula:
C16H14F3IN2O4
Target:
Apoptosis,Autophagy,MEK
Application Notes:
Reference compound
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