(E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells[1].
Molecular Weight:
485.94
Purity:
99.98
CAS Number:
[439081-18-2]
Formula:
C24H25ClFN5O3
Target:
Akt,Apoptosis,Autophagy,c-Met/HGFR,EGFR,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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