Gusacitinib-d4 (ASN-002-d4) is the deuterium labeled Gusacitinib (HY-103018). Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2].
Molecular Weight:
464.56
Formula:
C24H24D4N8O2
Target:
Isotope-Labeled Compounds,JAK,Syk
Application Notes:
MCE Product type: Isotope-Labeled Compounds
* VAT and and shipping costs not included. Errors and price changes excepted
