CMF019 is an orally active, potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents[1]. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension[1][2][3][4].
Molecular Weight:
455.61
Purity:
99.89
CAS Number:
[1586787-08-7]
Formula:
C25H33N3O3S
Target:
Apelin Receptor (APJ)
Application Notes:
MCE Product type: Reference compound
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