NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].
Molecular Weight:
546.09
Purity:
99.86
CAS Number:
[138605-00-2]
Formula:
C27H44ClNO8
Target:
Adenylate Cyclase
Application Notes:
MCE Product type: Reference compound
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