Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38alpha=38 nM, for p38beta=65 nM, for p38gamma=200 nM, and for p38delta=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM[1][2].
Molecular Weight:
527.66
Purity:
99.98
CAS Number:
[285983-48-4]
Formula:
C31H37N5O3
Target:
Autophagy,p38 MAPK,Raf
Application Notes:
MCE Product type: Reference compound
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