CL-387785 (EKI-785, WAY-EKI 785) is an orally active EGFR inhibitor with an IC50 of 370 pM. CL-387785 inhibits EGF-stimulated EGFR autophosphorylation with an IC50 of approximately 5 nM. CL-387,785 exerts selective inhibition on cell lines overexpressing EGFR or c-erbB-2, whereas it shows weak inhibitory effects on cell lines with low expression of these two receptors. CL-387785 effectively induces cell cycle arrest and apoptosis. CL-387785 can be used for the research of non-small cell lung cancer and autosomal recessive polycystic kidney disease[1][2][3].
Molecular Weight:
381.23
Purity:
99.1100
CAS Number:
[194423-06-8]
Formula:
C18H13BrN4O
Target:
Apoptosis,EGFR
Application Notes:
MCE Product type: Reference compound
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