ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 µM in the cAMP assay, and 1.75 µM in the beta-arrestin assay, and EC80 of 10 nM in both assays.
Molecular Weight:
385.35
Purity:
99.01
CAS Number:
[877636-42-5]
Formula:
C17H11N3O6S
Target:
Apelin Receptor (APJ),Arrestin
Application Notes:
MCE Product type: Reference compound
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