ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].
Molecular Weight:
369.33
Purity:
99.49
CAS Number:
[1346233-68-8]
Formula:
C19H26Cl2N2O
Target:
Calcium Channel
Application Notes:
MCE Product type: Reference compound
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