Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRbeta, Kit, RET and Raf-1, respectively. Regorafenib shows very robust antitumor and antiangiogenic activity[1].
Molecular Weight:
482.82
Purity:
99.93
CAS Number:
[755037-03-7]
Formula:
C21H15ClF4N4O3
Target:
Autophagy,c-Kit,FGFR,PDGFR,Raf,RET,Tie,VEGFR
Application Notes:
MCE Product type: Reference compound
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