SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU (HY-90006)-resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases[1][2][3].
Molecular Weight:
378.38
Purity:
99.58
CAS Number:
[247580-43-4]
Formula:
C21H18N2O5
Target:
CCR,Thymidylate Synthase
Application Notes:
MCE Product type: Reference compound1
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