DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active COX-2 inhibitor (IC50 of 10 nM and 800 nM for human COX-2 and COX-1, respectively). DuP-697 exerts antiproliferative (IC50 of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects[1][2][3].
Molecular Weight:
411.31
Purity:
99.79
CAS Number:
[88149-94-4]
Formula:
C17H12BrFO2S2
Target:
Apoptosis,COX
Application Notes:
MCE Product type: Reference compound1
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