NCX 466 is an orally active COX-1 and COX-2 inhibitor that exhibits anti-inflammatory and analgesic effects. Additionally, NCX 466 acts as a NO donor, exerting anti-inflammatory and antioxidant effects by improving microcirculation. NCX 466 significantly reduces the levels of transforming growth factor-beta (TGF-beta) and oxidative stress markers (such as thiobarbituric acid reactive substances (TBARS) and 8-hydroxy-2-deoxyguanosine (8-OHdG)), and it decreases leukocyte recruitment during inflammation by reducing myeloperoxidase (MPO) activity, thereby preventing bleomycin (HY-108345)-induced pulmonary fibrosis in mice[1].
Molecular Weight:
436.41
CAS Number:
[1262956-64-8]
Formula:
C20H24N2O9
Target:
COX,Glutathione Peroxidase,TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound1
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