CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitive EGFR inhibitor with an IC50 of 0.3 µM. CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells, and dramatic inhibits and reverses the formation of beta-amyloid (Abeta42) fibril aggregates associated with Alzheimers disease[1][2].
Molecular Weight:
329.35
Purity:
99.82
CAS Number:
[145915-58-8]
Formula:
C20H15N3O2
Target:
Amyloid-beta,EGFR
Application Notes:
MCE Product type: Reference compound
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