HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation[1].
Molecular Weight:
574.05
Purity:
99.24
CAS Number:
[848133-17-5]
Formula:
C31H29ClFN5O3
Target:
EGFR
Application Notes:
MCE Product type: Reference compound
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