ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.
Molecular Weight:
513.73
Purity:
99.94
CAS Number:
[177583-70-9]
Formula:
C30H43NO4S
Target:
Estrogen Receptor/ERR
Application Notes:
MCE Product type: Reference compound
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